GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs9815354 | 1 | rs9311288 | chr3:41804581 | ULK4 | chr3:41288091-42003660:- | 1.02 | 11.16 | 5.5E-19 | Diastolic blood pressure |
| THYM | cis | rs9876781 | 1 | rs9311423 | chr3:48420308 | TREX1 | chr3:48501186-48509043:+ | -0.28 | -4.25 | 5.0E-5 | Longevity |
| THYM | cis | rs1875620 | 1 | rs9314664 | chr9:91561808 | C9orf47 | chr9:91605778-91611055:+ | -0.27 | -4.71 | 8.28E-6 | Response to statins (LDL cholesterol change) |
| THYM | cis | rs9457247 | 1 | rs932644 | chr6:167404187 | RNASET2 | chr6:167343008-167412795:- | -0.47 | -7.83 | 7.0E-12 | Crohn's disease |
| THYM | cis | rs7849270 | 1 | rs932833 | chr9:131884041 | CRAT | chr9:131857075-131873070:- | 0.38 | 4.61 | 1.24E-5 | Blood metabolite ratios |
| THYM | cis | rs7849270 | 1 | rs932835 | chr9:131887071 | CRAT | chr9:131857075-131873070:- | 0.42 | 4.98 | 2.82E-6 | Blood metabolite ratios |
| THYM | cis | rs10935120 | 1 | rs934093 | chr3:134195885 | ANAPC13 | chr3:134196547-134204865:- | 0.56 | 7.74 | 1.08E-11 | Height |
| THYM | cis | rs10935120 | 1 | rs934093 | chr3:134195885 | CEP63 | chr3:134204575-134293852:+ | 0.39 | 5.72 | 1.23E-7 | Height |
| THYM | cis | rs936229 | 1 | rs936228 | chr15:75132164 | ULK3 | chr15:75128459-75135552:- | -0.42 | -5.18 | 1.25E-6 | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) |
| THYM | cis | rs936229 | 1 | rs936229 | chr15:75132319 | ULK3 | chr15:75128459-75135552:- | -0.42 | -5.18 | 1.25E-6 | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) |
| THYM | cis | rs9362395 | 1 | rs9362395 | chr6:87854341 | C6orf163 | chr6:88057220-88075180:+ | -0.89 | -4.8 | 5.86E-6 | Schizophrenia |
| THYM | cis | rs9362426 | 1 | rs9362426 | chr6:88089874 | C6orf164 | chr6:88032306-88109459:+ | -0.47 | -4.71 | 8.48E-6 | Depressive episodes in bipolar disorder |
| THYM | cis | rs7246967 | 1 | rs936525 | chr19:23056189 | ZNF492 | chr19:22817126-22850472:+ | -0.5 | -5.66 | 1.61E-7 | Bronchopulmonary dysplasia |
| THYM | cis | rs7246967 | 1 | rs936526 | chr19:23055987 | ZNF492 | chr19:22817126-22850472:+ | -0.5 | -5.66 | 1.61E-7 | Bronchopulmonary dysplasia |
| THYM | cis | rs9369898 | 1 | rs9369898 | chr6:49382193 | CENPQ | chr6:49431096-49460820:+ | -0.3 | -5.65 | 1.67E-7 | Homocysteine levels |